Reproductive variables and Correlation between Irrational Parenthood Cognition and Destructive Behaviors of Marital Relationship in Infertile Women

Background: Reproductive variables may play an important role on the correlation between irrational parenthood cognition (IPC) and destructive behaviors of infertile couple. Objectives: The aim of this study was to determine the correlation between IPC and destructive behaviors by reproductive variables in primary infertile women. Methods: The study was descriptive-analytic. 183 cases of primary infertile women living in Zanjan-Iran and attended to the Infertility Clinic in Ayatollah Mousavi Hospital were investigated from 2015 to the end of 2016. The instrument included a three-part questionnaire of individual and reproductive information, IPC, and the destructive behaviors of marital relationship based on Glaser's choice theory. Data were analyzed by SPSS software using descriptive and Pearson correlation test (P<0.05). Results: There was a significant direct correlation between IPC and destructive behaviors of marital relationship in infertile women (r=0.47, p<0.001). Based on reproductive variables, the highest correlation was observed in the subgroups of less than 10 years elapsed from the diagnosis of infertility, less than 10 years from the onset of infertility treatment, and the expectation of pregnancy under 10 years, a history of twice unsuccessful in vitro fertilization, a tendency to pregnancy due to the pressure of the others and the cause of the unknown infertility (P<0.05). Correlation between IPC and all components of destructive behaviors was significant (p<0.001). Conclusion: Identifying infertile women with high IPC and destructive behaviors is important to educate regarding life skills and provide counseling services

Targeted Gene Panel Sequencing for Early-onset Inflammatory Bowel Disease and Chronic Diarrhea

Background: In contrast to adult-onset inflammatory bowel disease (IBD), where many genetic loci have been shown to be involved in complex disease etiology, early-onset IBD (eoIBD) and associated syndromes can sometimes present as monogenic conditions. As a result, the clinical phenotype and ideal disease management in these patients often differ from those in adult-onset IBD. However, due to high costs and the complexity of data analysis, high-throughput screening for genetic causes has not yet become a standard part of the diagnostic work-up of eoIBD patients. Methods: We selected 28 genes of interest associated with monogenic IBD and performed targeted panel sequencing in 71 patients diagnosed with eoIBD or early-onset chronic diarrhea to detect causative variants. We compared these results to whole-exome sequencing (WES) data available for 25 of these patients. Results: Target coverage was significantly higher in the targeted gene panel approach compared with WES, whereas the cost of the panel was considerably lower (approximately 25% of WES). Disease-causing variants affecting protein function were identified in 5 patients (7%), located in genes of the IL10 signaling pathway (3), WAS (1), and DKC1 (1). The functional effects of 8 candidate variants in 5 additional patients (7%) are under further investigation. WES did not identify additional causative mutations in 25 patients. Conclusions: Targeted gene panel sequencing is a fast and effective screening method for monogenic causes of eoIBD that should be routinely established in national referral centers.info:eu-repo/semantics/publishedVersio

The Effect of Vitamin E on Ameliorating Primary Dysmenorrhea: A Systematic Review and Meta‑analysis

Dysmenorrhea or painful menstruation is one of the most common problems of women. Using systematic review and meta‑analysis, this study aimed to determine the effect of vitamin E on ameliorating the intensity of pain of primary dysmenorrhea. Available databases comprising PubMed, Google Scholar, ISI, Science Direct, SID, Iran Medex, and Magiran were searched to find relevant papers. Clinical trials with the aim of the effect of vitamin E on pain reduction of primary dysmenorrhea were selected. Two independent reviewers assessed the quality of studies and extracted the necessary data. Three studies were eligible for meta‑analysis. The meta‑analysis of these studies showed that vitamin E (with or without mefenamic acid), could reduce the intensity of pain about 7% (95% CI: 2-30%). Based on these studies, vitamin E can reduce the intensity of primary dysmenorrhea.Keywords: Complimentary medicine, dysmenorrhea, vitamin